翻訳と辞書 Words near each other ・ Subliminal Plastic Motives ・ Subliminal Sandwich ・ Subliminal Sessions 6 ・ Subliminal Simulation ・ Subliminal Sounds ・ Subliminal stimuli ・ Sublimity (album) ・ Sublimity (disambiguation) ・ Sublimity (horse) ・ Sublimity City, Kentucky ・ Sublimity, Oregon ・ Sublimotion ・ Sublimus Dei ・ Sublinear function ・ Sublingua ・ Sublingual administration ・ Sublingual caruncle ・ Sublingual fovea ・ Sublingual gland ・ Sublingual nucleus ・ Sublingual papilla ・ Sublingual space ・ Sublingual vein ・ Sublink Network ・ Subliterature ・ SubLOGIC ・ Sublogic ・ Sublogic Corporation ・ Sublunary sphere ・ Sublunary Tragedies Dictionary Lists mini英和辞書 mini和英辞書 Webster 1913 Latin-English FOLDOC Wikipedia English ウィキペディア

翻訳と辞書　辞書検索 [ 開発暫定版 ] スポンサード リンク Sublingual administration ： ウィキペディア英語版 Sublingual administration Sublingual (abbreviated SL), from the Latin for "under the tongue", refers to the pharmacological route of administration by which drugs diffuse into the blood through tissues under the tongue. Many drugs are designed for sublingual administration, including cardiovascular drugs, steroids, barbiturates, enzymes and, increasingly, vitamins and minerals. == Principle == When a chemical comes in contact with the mucous membrane beneath the tongue, it diffuses through it. Because the connective tissue beneath the epithelium contains a profusion of capillaries, the substance then diffuses into them and enters the venous circulation. In contrast, substances absorbed in the intestines are subject to "first-pass metabolism" in the liver before entering the general circulation. Sublingual administration has certain advantages over oral administration. Being more direct, it is often faster, and it ensures that the substance will risk degradation only by salivary enzymes before entering the bloodstream, whereas orally administered drugs must survive passage through the hostile environment of the gastrointestinal tract, which risks degrading them, either by stomach acid or bile, or by the many enzymes therein, such as monoamine oxidase (MAO). Furthermore, after absorption from the gastrointestinal tract, such drugs must pass to the liver, where they may be extensively altered; this is known as the first pass effect of drug metabolism. Due to the digestive activity of the stomach and intestines and the solubility of the GI tract, the oral route is unsuitable for certain substances, such as salvinorin A. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Sublingual administration」の詳細全文を読む スポンサード リンク 翻訳と辞書 : 翻訳のためのインターネットリソース Copyright(C) kotoba.ne.jp 1997-2016. All Rights Reserved.